Resources

A Mammalian Cell Cycle Checkpoint Pathway Utilizing p53 and GADD45 is Defective in Ataxia-Telangiectasia

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Definition of a consensus binding site for p53

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Topological Control of p21WAF1/CIP1 Expression in Normal and Neoplastic Tissues

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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Regulation of p53 downstream genes

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Molecular Cloning and Functional Analysis of the Mouse Homologue of the KILLER/DR5 Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Death Receptor1

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Pointing (zinc) fingers at BRCA1 targets

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Repression of BRCA1 through a Feedback Loop Involving p53

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Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

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Death Domain Mutagenesis of KILLER/DR5 Reveals Residues Critical for Apoptotic Signaling

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Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic Approach*

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Tissue-specific Induction of p53 Targets in Vivo1

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The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein

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BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) in the DNA Repair Response Following UV-Irradiation

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BID regulation by p53 contributes to chemosensitivity

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BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

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Stabilization of p53 by CP-31398 Inhibits Ubiquitination without Altering Phosphorylation at Serine 15 or 20 or MDM2 Binding

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Identification and Characterization of the Cytoplasmic Protein TRAF4 as a p53-regulated Proapoptotic Gene

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Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy

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Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity

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Nature’s TRAIL— Minireview On a Path to Cancer Immunotherapy

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The role of p53 in chemosensitivity and radiosensitivity

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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

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Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9

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Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth

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Death Induction by Recombinant Native TRAIL and Its Prevention by a Caspase 9 Inhibitor in Primary Human Esophageal Epithelial Cells

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Inducible Silencing of KILLER/DR5 In vivo Promotes Bioluminescent Colon Tumor Xenograft Growth and Confers Resistance to Chemotherapeutic Agent 5-Fluorouracil

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DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis

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Overview of Cell Death Signaling Pathways

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Meeting Report: The International Conference on Tumor Progression and Therapeutic Resistance

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Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis

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p73 or p53 Directly Regulates Human p53 Transcription to Maintain Cell Cycle Checkpoints

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Tumorigenic Conversion of Primary Human Esophageal Epithelial Cells Using Oncogene Combinations in the Absence of Exogenous Ras

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Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts

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Imaging and Oncologic Drug Development

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Multimodality Optical Imaging and 18F-FDG Uptake in Wild-Type p53-Containing and p53-Null Human Colon Tumor Xenografts

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Cell Cycle–Dependent and Schedule-Dependent Antitumor Effects of Sorafenib Combined with Radiation

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Invincible, but Not Invisible: Imaging Approaches Toward In Vivo Detection of Cancer Stem Cells

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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

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Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras

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Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3 b and CDK1

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High-Resolution Imaging and Antitumor Effects of GFP Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors

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Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients

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Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

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Off-Target Lapatinib Activity Sensitizes Colon Cancer Cells Through TRAIL Death Receptor Up-Regulation

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Genetics of Aging and Longevity

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Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

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