Resources

Publications

1990-'94

High Expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer

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WAF1, a Potential Mediator of p53 Tumor Suppression

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1995 - '99

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

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Regulation of p53 downstream genes

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2000 - '04

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

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The role of p53 in chemosensitivity and radiosensitivity

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2005 - '09

Meeting Report: The International Conference on Tumor Progression and Therapeutic Resistance

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Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis

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2010 - Current

Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients

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Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3 b and CDK1

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Quest For Answers
"We're trying to understand how cancer cells die, how they're affected by chemotherapy or newer agents, why they become resistant to certain treatments and how to develop strategies to reverse the resistance," says Wafik El-Deiry, MD, PhD, chief of hematology/oncology at Penn State Hershey Medical Center
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Kuwait Prize In Applied Sciences
Dr. El-Deiry was recognized for his work on tumor suppressor genes including p53 and TRAIL, and mechanisms that determine cancer therapeutic response. Dr. El-Deiry was recognized for developing new strategies targeting cell death for cancer therapy.
Read the full article from Cancer Biology & Therapy

Small Molecule Drug Drives Cancer Cells to Suicide
Cancer researchers have pinned down a molecule that can kick-start the body's own tumour-destroying systems, triggering cell death in cancerous but not healthy tissue in mice.
Read the full article from Nature News